| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZDHHC15 (238-337) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC15 |
| Gene ID: |
158866 |
| Uniprot ID: |
ZDH15_HUMAN |
| Immunogen Region: |
238-337 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 238-337 of human ZDHHC15 (NP_659406.1). |
| Immunogen Sequence: |
VSRNKTTLEAFCTPVFTSGP EKNGFNLGFIKNIQQVFGDK KKFWLIPIGSSPGDGHSFPM RSMNESQNPLLANEETWEDN EDDNQDYPEGSSSLAVETET |
| Tissue Specificity | Expressed in placenta, liver, lung, kidney, heart and brain. |
| Post Translational Modifications | Autopalmitoylated (in vitro). |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex. Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins. In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis. Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon. Could also catalyze the palmitoylation of GAP43. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate FYN as shown in vitro. |
| Protein Name | Palmitoyltransferase Zdhhc15Acyltransferase Zdhhc15Zinc Finger Dhhc Domain-Containing Protein 15Dhhc-15 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinPostsynaptic Density |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc15 antibodyAnti-Acyltransferase Zdhhc15 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 15 antibodyAnti-Dhhc-15 antibodyAnti-ZDHHC15 antibodyAnti-UNQ1969 antibodyAnti-PRO4501 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
