| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GET1 |
| Gene ID: | 7485 |
| Uniprot ID: | GET1_HUMAN |
| Immunogen Region: | 30-100 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human WRB (NP_004618.2). |
| Immunogen Sequence: | SFSSFMSRVLQKDAEQESQM RAEIQDMKQELSTVNMMDEF ARYARLERKINKMTDKLKTH VKARTAQLAKI |
| Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG. |
| Protein Name | Guided Entry Of Tail-Anchored Proteins Factor 1Congenital Heart Disease 5 ProteinTail-Anchored Protein Insertion Receptor WrbTryptophan-Rich Basic Protein |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Guided Entry Of Tail-Anchored Proteins Factor 1 antibodyAnti-Congenital Heart Disease 5 Protein antibodyAnti-Tail-Anchored Protein Insertion Receptor Wrb antibodyAnti-Tryptophan-Rich Basic Protein antibodyAnti-GET1 antibodyAnti-CHD5 antibodyAnti-WRB antibody |
Information sourced from Uniprot.org