Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-WRB (30-100) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GET1 |
Gene ID: | 7485 |
Uniprot ID: | GET1_HUMAN |
Immunogen Region: | 30-100 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human WRB (NP_004618.2). |
Immunogen Sequence: | SFSSFMSRVLQKDAEQESQM RAEIQDMKQELSTVNMMDEF ARYARLERKINKMTDKLKTH VKARTAQLAKI |
Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG. |
Protein Name | Guided Entry Of Tail-Anchored Proteins Factor 1 Congenital Heart Disease 5 Protein Tail-Anchored Protein Insertion Receptor Wrb Tryptophan-Rich Basic Protein |
Database Links | Reactome: R-HSA-9609523 |
Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
Alternative Antibody Names | Anti-Guided Entry Of Tail-Anchored Proteins Factor 1 antibody Anti-Congenital Heart Disease 5 Protein antibody Anti-Tail-Anchored Protein Insertion Receptor Wrb antibody Anti-Tryptophan-Rich Basic Protein antibody Anti-GET1 antibody Anti-CHD5 antibody Anti-WRB antibody |
Information sourced from Uniprot.org