| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway. |
| Protein Name | Ww Domain-Containing Adapter Protein With Coiled-Coil |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Nucleus SpeckleNucleusIn Distinct Nuclear SpecklesColocalizes With Pre-Mrna Processing Complexes |
| Alternative Antibody Names | Anti-Ww Domain-Containing Adapter Protein With Coiled-Coil antibodyAnti-WAC antibodyAnti-KIAA1844 antibody |
Information sourced from Uniprot.org
