| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WAC (1-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WAC |
| Gene ID: |
51322 |
| Uniprot ID: |
WAC_HUMAN |
| Immunogen Region: |
1-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human WAC (NP_057712.2). |
| Immunogen Sequence: |
MVMYARKQQRLSDGCHDRRG DSQPYQALKYSSKSHPSSGD HRHEKMRDAGDPSPPNKMLR RSDSPENKYSDSTGHSKAKN VHTHRVRERDGGTSYSPQEN SHNHSALHSSNSHSSNPSNN PSKTSDAPYDSADDWSEHIS SSGKKYYYNCRTEVSQWEKP KEWLEREQRQKEANKMAVNS FPKDRDYRREVMQATATSGF ASGMEDKHSSDASSLLPQNI LSQTSRHNDRDYRLPRAET |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway. |
| Protein Name | Ww Domain-Containing Adapter Protein With Coiled-Coil |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Nucleus SpeckleNucleusIn Distinct Nuclear SpecklesColocalizes With Pre-Mrna Processing Complexes |
| Alternative Antibody Names | Anti-Ww Domain-Containing Adapter Protein With Coiled-Coil antibodyAnti-WAC antibodyAnti-KIAA1844 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
