| Post Translational Modifications | Phosphorylated at Ser-108 by CDK5.leading to protection of the cell against H2O2-induced apoptosis. Ubiquitinated by RNF144A. |
| Function | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis. Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death. For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase. |
| Protein Name | Serine/Threonine-Protein Kinase Vrk3Vaccinia-Related Kinase 3 |
| Database Links | Reactome: R-HSA-202670 |
| Cellular Localisation | NucleusCytoplasmUnder Oxidative StressMigrates From The Nucleus To The Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Vrk3 antibodyAnti-Vaccinia-Related Kinase 3 antibodyAnti-VRK3 antibody |
Information sourced from Uniprot.org
