| Function | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 51 HomologAnother New Gene 2 ProteinProtein Fat-Free Homolog |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkRecycling EndosomeLocalizes To The Trans-Golgi Network As Part Of The Garp ComplexWhile It Localizes To Recycling Endosomes As Part Of The Earp Complex |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 51 Homolog antibodyAnti-Another New Gene 2 Protein antibodyAnti-Protein Fat-Free Homolog antibodyAnti-VPS51 antibodyAnti-ANG2 antibodyAnti-C11orf2 antibodyAnti-C11orf3 antibodyAnti-FFR antibodyAnti-PP5382 antibody |
Information sourced from Uniprot.org
