| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VPS51 |
| Gene ID: | 738 |
| Uniprot ID: | VPS51_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human VPS51 (NP_037397.2). |
| Immunogen Sequence: | MAAAAAAGPSPGSGPGDSPE GPEGEAPERRRKAHGMLKLY YGLSEGEAAGRPAGPDPLDP TDLNGAHFDPEVYLDKLRRE CPLAQLMDSETDMVRQIRAL DSDMQTLVYENYNKFISATD TIRKMKNDFRKMEDEMDRLA TNMAVITDFSARISATLQDR HERITKLAGVHALLRKLQFL FELPSRLTKCVELGAYGQAV RYQGRAQAVLQQYQHLPSFR AIQDDCQVITARLAQQLRQ |
| Function | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 51 Homolog Another New Gene 2 Protein Protein Fat-Free Homolog |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Recycling Endosome Localizes To The Trans-Golgi Network As Part Of The Garp Complex While It Localizes To Recycling Endosomes As Part Of The Earp Complex |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 51 Homolog antibody Anti-Another New Gene 2 Protein antibody Anti-Protein Fat-Free Homolog antibody Anti-VPS51 antibody Anti-ANG2 antibody Anti-C11orf2 antibody Anti-C11orf3 antibody Anti-FFR antibody Anti-PP5382 antibody |
Information sourced from Uniprot.org