| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-VGF (466-615) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VGF |
| Gene ID: |
7425 |
| Uniprot ID: |
VGF_HUMAN |
| Immunogen Region: |
466-615 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 466-615 of human VGF (NP_003369.2). |
| Immunogen Sequence: |
ADDVVSIIEEVEEKRKRKKN APPEPVPPPRAAPAPTHVRS PQPPPPAPAPARDELPDWNE VLPPWDREEDEVYPPGPYHP FPNYIRPRTLQPPSALRRRH YHHALPPSRHYPGREAQARR AQEEAEAEERRLQEQEELEN YIEHVLLRRP |
| Tissue Specificity | Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. |
| Post Translational Modifications | Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure. |
| Function | Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain. Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. Neuroendocrine regulatory peptide-2: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying. VGF-derived peptide TLQP-21: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity. VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization. Antimicrobial peptide VGF554-577: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. |
| Protein Name | Neurosecretory Protein Vgf Cleaved Into - Neuroendocrine Regulatory Peptide-1Nerp-1 - Neuroendocrine Regulatory Peptide-2Nerp-2 - Vgf-Derived Peptide Tlqp-21 - Vgf-Derived Peptide Tlqp-62 - Antimicrobial Peptide Vgf554-577 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9031628 |
| Cellular Localisation | Neurosecretory Protein Vgf: SecretedCytoplasmic VesicleSecretory VesicleStored In Secretory Vesicles And Then SecretedNerp Peptides Colocalize With Vasopressin In The Storage Granules Of Hypothalamus |
| Alternative Antibody Names | Anti-Neurosecretory Protein Vgf Cleaved Into - Neuroendocrine Regulatory Peptide-1 antibodyAnti-Nerp-1 - Neuroendocrine Regulatory Peptide-2 antibodyAnti-Nerp-2 - Vgf-Derived Peptide Tlqp-21 - Vgf-Derived Peptide Tlqp-62 - Antimicrobial Peptide Vgf554-577 antibodyAnti-VGF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
