| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FIGF (20-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VEGFD |
| Gene ID: |
2277 |
| Uniprot ID: |
VEGFD_HUMAN |
| Immunogen Region: |
20-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human VEGF-D (NP_004460.1). |
| Immunogen Sequence: |
QGSSNEHGPVKRSSQSTLER SEQQIRAASSLEELLRITHS EDWKLWRCRLRLKSFTSMDS RSASHRSTRFAATFYDIETL KVIDEEWQRTQCSPRETCVE VASELGKSTNTFFKPPCVNV FRCGGCCNEESLICMNTSTS YISKQLFEISVPLTSVPELV PVKVANHTGCKCLPTAPRHP YSIIRRSIQIPEEDRCSHSK K |
| Tissue Specificity | Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. |
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. |
| Protein Name | Vascular Endothelial Growth Factor DVegf-DC-Fos-Induced Growth FactorFigf |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vascular Endothelial Growth Factor D antibodyAnti-Vegf-D antibodyAnti-C-Fos-Induced Growth Factor antibodyAnti-Figf antibodyAnti-VEGFD antibodyAnti-FIGF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
