| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UNG |
| Gene ID: | 7374 |
| Uniprot ID: | UNG_HUMAN |
| Immunogen Region: | 1-313 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1). |
| Immunogen Sequence: | MIGQKTLYSFFSPSPARKRH APSPEPAVQGTGVAGVPEES GDAAAIPAKKAPAGQEEPGT PPSSPLSAEQLDRIQRNKAA ALLRLAARNVPVGFGESWKK HLSGEFGKPYFIKLMGFVAE ERKHYTVYPPPHQVFTWTQM CDIKDVKVVILGQDPYHGPN QAHGLCFSVQRPVPPPPSLE NIYKELSTDIEDFVHPGHGD LSGWAKQGVLLLNAVLTVRA HQANSHKERGWEQFTDAVV |
| Tissue Specificity | Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. |
| Post Translational Modifications | Isoform 1 is processed by cleavage of a transit peptide. |
| Function | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. |
| Protein Name | Uracil-Dna GlycosylaseUdg |
| Database Links | Reactome: R-HSA-110328 P13051-1Reactome: R-HSA-110329 P13051-1Reactome: R-HSA-110357 P13051-1Reactome: R-HSA-9821002 |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Uracil-Dna Glycosylase antibodyAnti-Udg antibodyAnti-UNG antibodyAnti-DGU antibodyAnti-UNG1 antibodyAnti-UNG15 antibody |
Information sourced from Uniprot.org