| Host: |
Rabbit |
| Applications: |
IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
UNC5A |
| Gene ID: |
90249 |
| Uniprot ID: |
UNC5A_HUMAN |
| Immunogen Region: |
230-300 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 230-300 of human UNC5A (NP_588610.2). |
| Immunogen Sequence: |
RRSASAAVIVYVDGSWSPWS KWSACGLDCTHWRSRECSDP APRNGGEECQGTDLDTRNCT SDLCVHTASGP |
| Post Translational Modifications | Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. The two extracellular TSRs of UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. |
| Function | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| Protein Name | Netrin Receptor Unc5aProtein Unc-5 Homolog 1Protein Unc-5 Homolog A |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-418886Reactome: R-HSA-418889 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCell ProjectionNeuron ProjectionThe Interaction With Prkcabp Regulates Its Surface Expression And Leads To Its Removal From The Surface Of Neurons And Growth Cones |
| Alternative Antibody Names | Anti-Netrin Receptor Unc5a antibodyAnti-Protein Unc-5 Homolog 1 antibodyAnti-Protein Unc-5 Homolog A antibodyAnti-UNC5A antibodyAnti-KIAA1976 antibodyAnti-UNC5H1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
