| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCB10 (230-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCB10 |
| Gene ID: |
23456 |
| Uniprot ID: |
ABCBA_HUMAN |
| Immunogen Region: |
230-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 230-300 of human ABCB10 (NP_036221.2). |
| Immunogen Sequence: |
AIRVYLMQTSGQRIVNRLRT SLFSSILRQEVAFFDKTRTG ELINRLSSDTALLGRSVTEN LSDGLRAGAQA |
| Tissue Specificity | Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon. |
| Function | Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner. May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria. Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 10 - MitochondrialAbc-Mitochondrial Erythroid ProteinAbc-Me ProteinAtp-Binding Cassette Transporter 10Abc Transporter 10 ProteinMitochondrial Atp-Binding Cassette 2M-Abc2 |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial antibodyAnti-Abc-Mitochondrial Erythroid Protein antibodyAnti-Abc-Me Protein antibodyAnti-Atp-Binding Cassette Transporter 10 antibodyAnti-Abc Transporter 10 Protein antibodyAnti-Mitochondrial Atp-Binding Cassette 2 antibodyAnti-M-Abc2 antibodyAnti-ABCB10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
