| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UGT1A4 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UGT1A4 |
| Gene ID: |
54657 |
| Uniprot ID: |
UD14_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UGT1A4 (NP_009051.1). |
| Immunogen Sequence: |
MARGLQVPLPRLATGLLLLL SVQPWAESGKVLVVPTDGSP WLSMREALRELHARGHQAVV LTPEVNMHIKEEKFFTLTAY AVPWTQKEFDRVTLGYTQGF |
| Tissue Specificity | Isoform 1: Expressed in liver. Expressed in kidney, colon and small intestine. Not expressed in esophagus. Not expressed in skin. Isoform 2: Expressed in liver, kidney, colon, esophagus and small intestine. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis. Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption. Isoform 2: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a4Ugt1a4Bilirubin-Specific Udpgt Isozyme 2Hug-Br2Udp-Glucuronosyltransferase 1-4Udpgt 1-4Ugt1*4Ugt1-04Ugt1.4Udp-Glucuronosyltransferase 1-DUgt-1dUgt1d |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-189483Reactome: R-HSA-5579016Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a4 antibodyAnti-Ugt1a4 antibodyAnti-Bilirubin-Specific Udpgt Isozyme 2 antibodyAnti-Hug-Br2 antibodyAnti-Udp-Glucuronosyltransferase 1-4 antibodyAnti-Udpgt 1-4 antibodyAnti-Ugt1*4 antibodyAnti-Ugt1-04 antibodyAnti-Ugt1.4 antibodyAnti-Udp-Glucuronosyltransferase 1-D antibodyAnti-Ugt-1d antibodyAnti-Ugt1d antibodyAnti-UGT1A4 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
