| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBAC1 (176-405) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBAC1 |
| Gene ID: |
10422 |
| Uniprot ID: |
UBAC1_HUMAN |
| Immunogen Region: |
176-405 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 176-405 of human UBAC1 (NP_057256.2). |
| Immunogen Sequence: |
LFKKANAMLDEDEDERVDEA ALRQLTEMGFPENRATKALQ LNHMSVPQAMEWLIEHAEDP TIDTPLPGQAPPEAEGATAA ASEAAAGASATDEEARDELT EIFKKIRRKREFRADARAVI SLMEMGFDEKEVIDALRVNN NQQNAACEWLLGDRKPSPEE LDKGIDPDSPLFQAILDNPV VQLGLTNPKTLLAFEDMLEN PLNSTQWMNDPETGPVMLQI SRIFQTLNRT |
| Tissue Specificity | Ubiquitous. |
| Function | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome. |
| Protein Name | Ubiquitin-Associated Domain-Containing Protein 1Uba Domain-Containing Protein 1Glialblastoma Cell Differentiation-Related Protein 1Kip1 Ubiquitination-Promoting Complex Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin-Associated Domain-Containing Protein 1 antibodyAnti-Uba Domain-Containing Protein 1 antibodyAnti-Glialblastoma Cell Differentiation-Related Protein 1 antibodyAnti-Kip1 Ubiquitination-Promoting Complex Protein 2 antibodyAnti-UBAC1 antibodyAnti-GBDR1 antibodyAnti-KPC2 antibodyAnti-UBADC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
