| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TUSC3 (42-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TUSC3 |
| Gene ID: |
7991 |
| Uniprot ID: |
TUSC3_HUMAN |
| Immunogen Region: |
42-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 42-200 of human TUSC3 (NP_839952.1). |
| Immunogen Sequence: |
QKKKENLLAEKVEQLMEWSS RRSIFRMNGDKFRKFIKAPP RNYSMIVMFTALQPQRQCSV CRQANEEYQILANSWRYSSA FCNKLFFSMVDYDEGTDVFQ QLNMNSAPTFMHFPPKGRPK RADTFDLQRIGFAAEQLAKW IADRTDVHIRVFRPPNYSG |
| Tissue Specificity | Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. |
| Function | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues.in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Magnesium transporter. |
| Protein Name | Tumor Suppressor Candidate 3Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3Oligosaccharyl Transferase Subunit Tusc3Magnesium Uptake/Transporter Tusc3Protein N33 |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-5223345Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Suppressor Candidate 3 antibodyAnti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3 antibodyAnti-Oligosaccharyl Transferase Subunit Tusc3 antibodyAnti-Magnesium Uptake/Transporter Tusc3 antibodyAnti-Protein N33 antibodyAnti-TUSC3 antibodyAnti-N33 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
