Anti-TUSC3 antibody (42-200) (STJ114601)

SKU:
STJ114601

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TUSC3 (42-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TUSC3
Gene ID: 7991
Uniprot ID: TUSC3_HUMAN
Immunogen Region: 42-200
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-200 of human TUSC3 (NP_839952.1).
Immunogen Sequence: QKKKENLLAEKVEQLMEWSS RRSIFRMNGDKFRKFIKAPP RNYSMIVMFTALQPQRQCSV CRQANEEYQILANSWRYSSA FCNKLFFSMVDYDEGTDVFQ QLNMNSAPTFMHFPPKGRPK RADTFDLQRIGFAAEQLAKW IADRTDVHIRVFRPPNYSG
Tissue Specificity Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.
Function Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues.in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Magnesium transporter.
Protein Name Tumor Suppressor Candidate 3
Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3
Oligosaccharyl Transferase Subunit Tusc3
Magnesium Uptake/Transporter Tusc3
Protein N33
Database Links Reactome: R-HSA-446203
Reactome: R-HSA-5223345
Reactome: R-HSA-9694548
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Tumor Suppressor Candidate 3 antibody
Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3 antibody
Anti-Oligosaccharyl Transferase Subunit Tusc3 antibody
Anti-Magnesium Uptake/Transporter Tusc3 antibody
Anti-Protein N33 antibody
Anti-TUSC3 antibody
Anti-N33 antibody

Information sourced from Uniprot.org

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