| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM35 (120-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM35 |
| Gene ID: |
23087 |
| Uniprot ID: |
TRI35_HUMAN |
| Immunogen Region: |
120-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human TRIM35 (NP_741983.2). |
| Immunogen Sequence: |
CCSCQADPRHQGHRVQPVKD TAHDFRAKCRNMEHALREKA KAFWAMRRSYEAIAKHNQVE AAWLEGRIRQEFDKLREFLR VEEQAILDAMAEETRQKQLL ADEKMKQLTEETEVLAHEIE RLQMEMKEDDVSFLMKHKSR KRRLFCTMEPEPVQPGMLID V |
| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim35Hemopoietic Lineage Switch Protein 5 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleusFound Predominantly In Cytoplasm With A Granular DistributionFound In Punctuate Nuclear Bodies |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim35 antibodyAnti-Hemopoietic Lineage Switch Protein 5 antibodyAnti-TRIM35 antibodyAnti-HLS5 antibodyAnti-KIAA1098 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
