| Tissue Specificity | Expressed in heart, skeletal muscle and tracheal epithelial cells. |
| Function | Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1. |
| Protein Name | Tonsoku-Like ProteinInhibitor Of Kappa B-Related ProteinI-Kappa-B-Related ProteinIkappabrNf-Kappa-B Inhibitor-Like Protein 2Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor-Like 2 |
| Cellular Localisation | NucleusChromosomeCytoplasmMainly NuclearLocalizes To Dna Damage SitesAccumulates At Stressed Replication ForksRecruited To Stalled Or Collapsed Replication Forks Following Histone Replacement By Histone Chaperones Asf1a And The Caf-1 Complex: Tonsl Acts As A Histone Reader That Recognizes And Binds Newly Synthesized Histones |
| Alternative Antibody Names | Anti-Tonsoku-Like Protein antibodyAnti-Inhibitor Of Kappa B-Related Protein antibodyAnti-I-Kappa-B-Related Protein antibodyAnti-Ikappabr antibodyAnti-Nf-Kappa-B Inhibitor-Like Protein 2 antibodyAnti-Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor-Like 2 antibodyAnti-TONSL antibodyAnti-IKBR antibodyAnti-NFKBIL2 antibody |
Information sourced from Uniprot.org
