| Tissue Specificity | Expressed at low levels in colon (at protein level). Expressed in prostate and placenta. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. |
| Protein Name | Tensin-4C-Terminal Tensin-Like Protein |
| Database Links | Reactome: R-HSA-8875513 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tensin-4 antibodyAnti-C-Terminal Tensin-Like Protein antibodyAnti-TNS4 antibodyAnti-CTEN antibodyAnti-PP14434 antibody |
Information sourced from Uniprot.org
