| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNIP2 (240-429) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNIP2 |
| Gene ID: |
79155 |
| Uniprot ID: |
TNIP2_HUMAN |
| Immunogen Region: |
240-429 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-429 of human TNIP2 (NP_077285.3). |
| Immunogen Sequence: |
GLHAQLRGLQIPHEPELMRK EISRLNRQLEEKINDCAEVK QELAASRTARDAALERVQML EQQILAYKDDFMSERADRER AQSRIQELEEKVASLLHQVS WRQDSREPDAGRIHAGSKTA KYLAADALELMVPGGWRPGT GSQQPEPPAEGGHPGAAQRG QGDLQCPHCLQCFSDEQGEE LLRHVAECCQ |
| Tissue Specificity | Ubiquitously expressed in all tissues examined. |
| Post Translational Modifications | In vitro phosphorylated by CHUK. Ubiquitinated.undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35.leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. |
| Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response.this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells.promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. |
| Protein Name | Tnfaip3-Interacting Protein 2A20-Binding Inhibitor Of Nf-Kappa-B Activation 2Abin-2Fetal Liver Lkb1-Interacting Protein |
| Database Links | Reactome: R-HSA-5684264Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Tnfaip3-Interacting Protein 2 antibodyAnti-A20-Binding Inhibitor Of Nf-Kappa-B Activation 2 antibodyAnti-Abin-2 antibodyAnti-Fetal Liver Lkb1-Interacting Protein antibodyAnti-TNIP2 antibodyAnti-ABIN2 antibodyAnti-FLIP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
