| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TIM-1/KIM-1/HAVCR (22-237) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:8000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Havcr1 |
| Gene ID: |
171283 |
| Uniprot ID: |
HAVR1_MOUSE |
| Immunogen Region: |
22-237 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-237 of mouse TIM-1/KIM-1/HAVCR (NP_599009.2). |
| Immunogen Sequence: |
YVEVKGVVGHPVTLPCTYST YRGITTTCWGRGQCPSSACQ NTLIWTNGHRVTYQKSSRYN LKGHISEGDVSLTIENSVES DSGLYCCRVEIPGWFNDQKV TFSLQVKPEIPTRPPTRPTT TRPTATGRPTTISTRSTHVP TSIRVSTSTPPTSTHTWTHK PEPTTFCPHETTAEVTGIPS HTPTDWNGTVTSSGDTWSNH TEAIPPGKPQKNPTKG |
| Tissue Specificity | Expressed by stimulated T-cells. Expressed during primary antigen stimulation. Expressed at higher levels on B rather than T-cells, both constitutively and after activation. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation. May play a role in kidney injury and repair. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1 HomologHavcr-1Kidney Injury Molecule 1Kim-1T Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T Cell Membrane Protein 1T-Cell Immunoglobulin Mucin Receptor 1Tim-1Cd Antigen Cd365 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 Homolog antibodyAnti-Havcr-1 antibodyAnti-Kidney Injury Molecule 1 antibodyAnti-Kim-1 antibodyAnti-T Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibodyAnti-Timd-1 antibodyAnti-T Cell Membrane Protein 1 antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 1 antibodyAnti-Tim-1 antibodyAnti-Cd Antigen Cd365 antibodyAnti-Havcr1 antibodyAnti-Kim1 antibodyAnti-Tim1 antibodyAnti-Timd1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
