Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TGM3 (1-180) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:100-1:500 IF/ICC 1:10-1:100 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TGM3 |
Gene ID: | 7053 |
Uniprot ID: | TGM3_HUMAN |
Immunogen Region: | 1-180 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TGM3 (NP_003236.3). |
Immunogen Sequence: | MAALGVQSINWQTAFNRQAH HTDKFSSQELILRRGQNFQV LMIMNKGLGSNERLEFIVST GPYPSESAMTKAVFPLSNGS SGGWSAVLQASNGNTLTISI SSPASAPIGRYTMALQIFSQ GGISSVKLGTFILLFNPWLN VDSVFMGNHAEREEYVQEDA GIIFVGSTNRIGMIGWNFGQ |
Post Translational Modifications | Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 or between Pro-465 and Phe-466. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV. |
Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. |
Protein Name | Protein-Glutamine Gamma-Glutamyltransferase E Transglutaminase E Tg(E Tge Tgase E Transglutaminase-3 Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Protein-Glutamine Gamma-Glutamyltransferase E antibody Anti-Transglutaminase E antibody Anti-Tg(E antibody Anti-Tge antibody Anti-Tgase E antibody Anti-Transglutaminase-3 antibody Anti-Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain antibody Anti-TGM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance