| Host: | Rabbit |
| Applications: | IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TGFA (24-160) is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | IHC 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TGFA |
| Gene ID: | 7039 |
| Uniprot ID: | TGFA_HUMAN |
| Immunogen Region: | 24-160 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-160 of human TGFA (NP_003227.1). |
| Immunogen Sequence: | ENSTSPLSADPPVAAAVVSH FNDCPDSHTQFCFHGTCRFL VQEDKPACVCHSGYVGARCE HADLLAVVAASQKKQAITAL VVVSIVALAVLIITCVLIHC CQVRKHCEWCRALICRHEKP SALLKGRTACCHSETVV |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. |
| Function | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| Protein Name | Protransforming Growth Factor Alpha Cleaved Into - Transforming Growth Factor AlphaTgf-AlphaEgf-Like TgfEtgfTgf Type 1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-177929Reactome: R-HSA-179812Reactome: R-HSA-180292Reactome: R-HSA-180336Reactome: R-HSA-182971Reactome: R-HSA-204005Reactome: R-HSA-212718Reactome: R-HSA-2219530Reactome: R-HSA-5638303Reactome: R-HSA-5673001Reactome: R-HSA-5694530Reactome: R-HSA-6811558Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866910Reactome: R-HSA-9009391Reactome: R-HSA-9018519Reactome: R-HSA-9634638 |
| Cellular Localisation | Transforming Growth Factor Alpha: SecretedExtracellular SpaceProtransforming Growth Factor Alpha: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Protransforming Growth Factor Alpha Cleaved Into - Transforming Growth Factor Alpha antibodyAnti-Tgf-Alpha antibodyAnti-Egf-Like Tgf antibodyAnti-Etgf antibodyAnti-Tgf Type 1 antibodyAnti-TGFA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
