| Background | This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. |
| Tissue Specificity | Highly expressed and ubiquitous. Isoform Pin2 predominates. |
| Database Links | Reactome: R-HSA-110328 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleChromosomeTelomereColocalizes With Telomeric Dna In Interphase And Prophase CellsTelomeric Localization Decreases In MetaphaseAnaphase And TelophaseAssociates With The Mitotic Spindle |
| Protein Name | Telomeric Repeat-Binding Factor 1Nima-Interacting Protein 2Ttaggg Repeat-Binding Factor 1Telomeric Protein Pin2/Trf1 |
| Alternative Names | Anti-Telomeric Repeat-Binding Factor 1 antibodyAnti-Nima-Interacting Protein 2 antibodyAnti-Ttaggg Repeat-Binding Factor 1 antibodyAnti-Telomeric Protein Pin2/Trf1 antibodyAnti-TERF1 antibodyAnti-PIN2 antibodyAnti-TRBF1 antibodyAnti-TRF antibodyAnti-TRF1 antibody |
