Anti-TBC1D21 antibody (1-336) (STJ11100183)

SKU:
STJ11100183

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TBC1D21 (1-336) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TBC1D21
Gene ID: 161514
Uniprot ID: TBC21_HUMAN
Immunogen Region: 1-336
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human TBC1D21 (NP_699187.1).
Immunogen Sequence: MTTLSPENSLSARQSASFIL VKRKPPIDKTEWDSFFDESG HLAKSRDFICVNILERGLHP FVRTEAWKFLTGYFSWQSSQ DERLTVDSMRRKNYKALCQM YEKIQPLLENLHRNFTETRN NIARDIQKIYDKDPLGNVLI DKKRLEKILLLSYVCNTQAE YQQGFHEMMMLFQLMVEHDH ETFWLFQFFLQKTEHSCVIN IGVAKNLDMLSTLITFLDPV FAEHLKGKGAGAVQSLFPW
Tissue Specificity Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain.
Function Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.
Protein Name Tbc1 Domain Family Member 21
Male Germ Cell Rab Gtpase-Activating Protein
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Cytoplasm
Cytoskeleton
Located At The Edge Of The Acrosomal Region
Neck And Annulus During Spermiogenesis
Colocalizes With Rab3a At The Acrosome-Acroplaxome And Neck Regions Of Spermatids
Colocalizes With Actb At The Neck Region In Elongated Spermatids
Alternative Antibody Names Anti-Tbc1 Domain Family Member 21 antibody
Anti-Male Germ Cell Rab Gtpase-Activating Protein antibody
Anti-TBC1D21 antibody
Anti-MGCRABGAP antibody

Information sourced from Uniprot.org

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