| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBC1D21 (1-336) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBC1D21 |
| Gene ID: |
161514 |
| Uniprot ID: |
TBC21_HUMAN |
| Immunogen Region: |
1-336 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human TBC1D21 (NP_699187.1). |
| Immunogen Sequence: |
MTTLSPENSLSARQSASFIL VKRKPPIDKTEWDSFFDESG HLAKSRDFICVNILERGLHP FVRTEAWKFLTGYFSWQSSQ DERLTVDSMRRKNYKALCQM YEKIQPLLENLHRNFTETRN NIARDIQKIYDKDPLGNVLI DKKRLEKILLLSYVCNTQAE YQQGFHEMMMLFQLMVEHDH ETFWLFQFFLQKTEHSCVIN IGVAKNLDMLSTLITFLDPV FAEHLKGKGAGAVQSLFPW |
| Tissue Specificity | Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain. |
| Function | Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. |
| Protein Name | Tbc1 Domain Family Member 21Male Germ Cell Rab Gtpase-Activating Protein |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleAcrosomeCytoplasmCytoskeletonLocated At The Edge Of The Acrosomal RegionNeck And Annulus During SpermiogenesisColocalizes With Rab3a At The Acrosome-Acroplaxome And Neck Regions Of SpermatidsColocalizes With Actb At The Neck Region In Elongated Spermatids |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 21 antibodyAnti-Male Germ Cell Rab Gtpase-Activating Protein antibodyAnti-TBC1D21 antibodyAnti-MGCRABGAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
