| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Synaptotagmin-11 is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5016RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SYT11 |
| Gene ID: |
23208 |
| Uniprot ID: |
SYT11_HUMAN |
| Immunogen: |
Recombinant protein of human Synaptotagmin XI (SYT11). |
| Post Translational Modifications | Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation. Ubiquitination is inhibited by ATP13A2. |
| Function | Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway. |
| Protein Name | Synaptotagmin-11Synaptotagmin XiSytxi |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinPerikaryonGolgi ApparatusTrans-Golgi Network MembraneRecycling Endosome MembraneLysosome MembraneCytoplasmic VesiclePhagosomeCell ProjectionAxonDendritePostsynaptic DensityClathrin-Coated Vesicle MembraneLocalized In Vesicles That Travels In Axonal And Dendritic Shafts In Both Anterograde And Retrograde DirectionsIn Macrophages And MicrogliaRecruited In Phagosomes At Early Stages Of PhagocytosisFound In The Core Of The Lewy Bodies In The Brain Of Sporadic Parkinson Disease Patients |
| Alternative Antibody Names | Anti-Synaptotagmin-11 antibodyAnti-Synaptotagmin Xi antibodyAnti-Sytxi antibodyAnti-SYT11 antibodyAnti-KIAA0080 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
