| Tissue Specificity | Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system. |
| Post Translational Modifications | Autophosphorylated. |
| Function | Serine/threonine protein kinase required for spermatid differentiation and male fertility. Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4. Also phosphorylates VIME, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton. |
| Protein Name | Serine/Threonine-Protein Kinase 33 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionColocalizes With The Caudal End Of The ManchetteA Transient Structure That Guides Tail Elongation In Elongating Spermatids |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 33 antibodyAnti-STK33 antibody |
Information sourced from Uniprot.org
