| Tissue Specificity | Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level). |
| Function | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. |
| Protein Name | Single-Stranded Dna-Binding Protein - MitochondrialMt-SsbMtssbPwp1-Interacting Protein 17 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-9837999 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Single-Stranded Dna-Binding Protein - Mitochondrial antibodyAnti-Mt-Ssb antibodyAnti-Mtssb antibodyAnti-Pwp1-Interacting Protein 17 antibodyAnti-SSBP1 antibodyAnti-SSBP antibody |
Information sourced from Uniprot.org
