| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SS18 |
| Gene ID: | 6760 |
| Uniprot ID: | SSXT_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SS18 (NP_001007560.1). |
| Immunogen Sequence: | MSVAFAAPRQRGKGEITPAA IQKMLDDNNHLIQCIMDSQN KGKTSECSQYQQMLHTNLVY LATIADSNQNMQSLLPAPPT QNMPMGPGGMNQSGPPPPPR SHNMPSDGMVGGGPPAPHMQ NQMNGQMPGPNHMPMQGPGP NQLNMTNSSMNMPSSSHGSM GGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQP NQGPMMHQQPPSQQYNMPQG GGQHYQGQQPPMGMMGQVN |
| Tissue Specificity | Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas. |
| Function | Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. |
| Protein Name | Protein SsxtProtein SytSynovial Sarcoma Translocated To X Chromosome Protein |
| Database Links | Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Ssxt antibodyAnti-Protein Syt antibodyAnti-Synovial Sarcoma Translocated To X Chromosome Protein antibodyAnti-SS18 antibodyAnti-SSXT antibodyAnti-SYT antibody |
Information sourced from Uniprot.org