| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPRY4 (30-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPRY4 |
| Gene ID: |
81848 |
| Uniprot ID: |
SPY4_HUMAN |
| Immunogen Region: |
30-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-210 of human SPRY4 (NP_112226.2). |
| Immunogen Sequence: |
QSAPLTPNSVMVQPLLDSRM SHSRLQHPLTILPIDQVKTS HVENDYIDNPSLALTTGPKR TRGGAPELAPTPARCDQDVT HHWISFSGRPSSVSSSSSTS SDQRLLDHMAPPPVADQASP RAVRIQPKVVHCQPLDLKGP AVPPELDKHFLLCEACGKCK CKECASPRTLPSCWVCNQEC L |
| Function | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin. |
| Protein Name | Protein Sprouty Homolog 4Spry-4 |
| Cellular Localisation | CytoplasmCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideFound In The Cytoplasm In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor)Colocalizes With Tesk1 In Vesicular Spots In The Cytoplasm |
| Alternative Antibody Names | Anti-Protein Sprouty Homolog 4 antibodyAnti-Spry-4 antibodyAnti-SPRY4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
