• Western blot analysis of extracts of A-549 cells, using SNX17 antibody (STJ112312) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-SNX17 antibody (1-270) (STJ112312)

SKU:
STJ112312

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SNX17 (1-270) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNX17
Gene ID: 9784
Uniprot ID: SNX17_HUMAN
Immunogen Region: 1-270
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SNX17 (NP_055563.1).
Immunogen Sequence: MHFSIPETESRSGDSGGSAY VAYNIHVNGVLHCRVRYSQL LGLHEQLRKEYGANVLPAFP PKKLFSLTPAEVEQRREQLE KYMQAVRQDPLLGSSETFNS FLRRAQQETQQVPTEEVSLE VLLSNGQKVLVNVLTSDQTE DVLEAVAAKLDLPDDLIGYF SLFLVREKEDGAFSFVRKLQ EFELPYVSVTSLRSQEYKIV LRKSYWDSAYDDDVMENRVG LNLLYAQTVSDIERGWILV
Function Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Protein Name Sorting Nexin-17
Cellular Localisation Cytoplasm
Early Endosome
Cytoplasmic Vesicle Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Sorting Nexin-17 antibody
Anti-SNX17 antibody
Anti-KIAA0064 antibody

Information sourced from Uniprot.org

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