| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Synphilin-1 (797-846 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNCAIP |
| Gene ID: | 9627 |
| Uniprot ID: | SNCAP_HUMAN |
| Immunogen Region: | 797-846 aa |
| Specificity: | Synphilin-1 Polyclonal Antibody detects endogenous levels of Synphilin-1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Synphilin-1 at the amino acid range 797-846 |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1, SIAH2 or RNF19A and leading to its subsequent proteasomal degradation. In the absence of proteasomal degradation, ubiquitinated SNCAIP accumulates in cytoplasmic inclusion bodies. Isoform 2 is subject to limited ubiquitination that does not lead to proteasomal degradation. |
| Function | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. |
| Protein Name | Synphilin-1Sph1Alpha-Synuclein-Interacting Protein |
| Database Links | Reactome: R-HSA-977225 Q9Y6H5-2 |
| Cellular Localisation | CytoplasmDetected In Cytoplasmic Inclusion BodiesTogether With Snca |
| Alternative Antibody Names | Anti-Synphilin-1 antibodyAnti-Sph1 antibodyAnti-Alpha-Synuclein-Interacting Protein antibodyAnti-SNCAIP antibody |
Information sourced from Uniprot.org