| Post Translational Modifications | Phosphorylated by SMG1. |
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg8Amplified In Breast Cancer Gene 2 ProteinProtein Smg-8 Homolog |
| Database Links | Reactome: R-HSA-975957 |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg8 antibodyAnti-Amplified In Breast Cancer Gene 2 Protein antibodyAnti-Protein Smg-8 Homolog antibodyAnti-SMG8 antibodyAnti-ABC2 antibodyAnti-C17orf71 antibody |
Information sourced from Uniprot.org
