| Function | Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. |
| Protein Name | Pre-Mrna-Splicing Factor Slu7Hslu7 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmPredominantly NuclearShuttling Between The Nucleus And The Cytoplasm Is Regulated By The Cchc-Type Zinc FingerUpon Uv-C Stress StimulusThe Nuclear Concentration Of The Protein DecreasesAffecting Alternative SplicingTranslocates From The Nucleus To The Cytoplasm After Heat Shock Cell TreatmentAccumulates In Cytoplasmic Vesicle-Like Organelles After Heat Shock TreatmentWhich May Represent Stress Granules |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Slu7 antibodyAnti-Hslu7 antibodyAnti-SLU7 antibody |
Information sourced from Uniprot.org
