| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLCO3A1 |
| Gene ID: | 28232 |
| Uniprot ID: | SO3A1_HUMAN |
| Immunogen Region: | 440-540 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 440-540 of human SLCO3A1 (NP_037404.2). |
| Immunogen Sequence: | FLGCDTGPVAGVTVPYGNST APGSALDPYSPCNNNCECQT DSFTPVCGADGITYLSACFA GCNSTNLTGCACLTTVPAEN ATVVPGKCPSPGCQEAFLTF L |
| Tissue Specificity | Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 1: Expressed in placental trophoblasts. Expressed in pancreas, kidney, liver, lung, brain, heart, cerebellum, peripheral blood leukocyte, colon, small intestine, ovary, testis, prostate, thyroid, thymus and spleen. Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas. In testis, detected in spermatogonia at different stages and absent from Sertoli cells. Expressed in the choroid plexus epithelium, at the basolateral membrane. In brain, also very abundant in the gray matter of the frontal cortex, but not associated with neuronal cell bodies. Not detected in the white matter. Isoform 2: Expressed in heart, brain, cerebellum, testis, lung, thyroid, spoleen and liver. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed within the tubules. In testis, also present in spermatogonia at different stages. In brain, expressed in the choroid plexus epithelium, at the apical membrane as well as in the subapical intracellular vesicular compartments. In brain, also associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. |
| Function | Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 3a1Oatp3a1Organic Anion Transporter Polypeptide-Related Protein 3Oatp-Rp3Oatprp3Organic Anion-Transporting Polypeptide DOatp-DPge1 TransporterSodium-Independent Organic Anion Transporter DSolute Carrier Family 21 Member 11 |
| Database Links | Reactome: R-HSA-879518 Q9UIG8-1 |
| Cellular Localisation | Isoform 1: Basolateral Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basolateral Membrane Of Choroid Plexus EpitheliumIsoform 2: Apical Cell MembraneBasal Cell MembraneLocalized To The Basal Membrane Of Sertoli CellsLocalized To The Apical Membrane Of Choroid Plexus Epithelium |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 3a1 antibodyAnti-Oatp3a1 antibodyAnti-Organic Anion Transporter Polypeptide-Related Protein 3 antibodyAnti-Oatp-Rp3 antibodyAnti-Oatprp3 antibodyAnti-Organic Anion-Transporting Polypeptide D antibodyAnti-Oatp-D antibodyAnti-Pge1 Transporter antibodyAnti-Sodium-Independent Organic Anion Transporter D antibodyAnti-Solute Carrier Family 21 Member 11 antibodyAnti-SLCO3A1 antibodyAnti-OATP3A1 antibodyAnti-OATPD antibodyAnti-SLC21A11 antibody |
Information sourced from Uniprot.org