| Function | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced. |
| Protein Name | Sodium-Coupled Monocarboxylate Transporter 1Apical Iodide TransporterElectrogenic Sodium Monocarboxylate CotransporterSodium Iodide-Related CotransporterSolute Carrier Family 5 Member 8 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-428643 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinExpressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells |
| Alternative Nanobody Names | Anti-Sodium-Coupled Monocarboxylate Transporter 1 nanobodyAnti-Apical Iodide Transporter nanobodyAnti-Electrogenic Sodium Monocarboxylate Cotransporter nanobodyAnti-Sodium Iodide-Related Cotransporter nanobodyAnti-Solute Carrier Family 5 Member 8 nanobodyAnti-SLC5A8 nanobodyAnti-AIT nanobodyAnti-SMCT nanobodyAnti-SMCT1 nanobody |
Information sourced from Uniprot.org
![Anti-SLC5A8 nanobody [SAA0962] (STJN000329)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200942/413124/STJN000329-SDS-PAGE-1__82134.1749232620.jpg?c=1 "Anti-SLC5A8 nanobody [SAA0962] (STJN000329)")
![Anti-SLC5A8 nanobody [SAA0962] (STJN000329)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200942/413124/STJN000329-SDS-PAGE-1__82134.1749232620.jpg?c=1 "Anti-SLC5A8 nanobody [SAA0962] (STJN000329)")
