Anti-SLC5A8 antibody (C-Term) (STJ13102142)

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STJ13102142-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC5A8 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Slc5a8
Gene ID: 216225
Uniprot ID: SC5A8_MOUSE
Immunogen Region: C-Term
Specificity: Specific for SLC5A8.
Immunogen: A synthetic peptide from c-terminal region of mouse Sodium coupled monocarboxylate transporter 1 (SLC5A8) conjugated to an immunogenic carrier protein was used as the antigen.
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced.
Protein Name Sodium-Coupled Monocarboxylate Transporter 1
Electrogenic Sodium Monocarboxylate Cotransporter
Solute Carrier Family 5 Member 8
Database Links Reactome: R-MMU-197264
Reactome: -MMU-428643
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Restricted To The Apical Cell Membrane Of Enterocytes
Alternative Antibody Names Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibody
Anti-Electrogenic Sodium Monocarboxylate Cotransporter antibody
Anti-Solute Carrier Family 5 Member 8 antibody
Anti-Slc5a8 antibody
Anti-Smct antibody
Anti-Smct1 antibody

Information sourced from Uniprot.org