Anti-SLC5A8 antibody (461-610 aa) (STJ11106533)

SKU:
STJ11106533
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: SLC5A8
Gene ID: 160728
Uniprot ID: SC5A8_HUMAN
Immunogen Region: 461-610 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 461-610 of human SLC5A8 (NP_666018.3).
Immunogen Sequence: QIYPPLPERTLPLHLDIQGC NSTYNETNLMTTTEMPFTTS VFQIYNVQRTPLMDNWYSLS YLYFSTVGTLVTLLVGILVS LSTGGRKQNLDPRYILTKED FLSNFDIFKKKKHVLSYKSH PVEDGGTDNPAFNHIELNSD QSGKSNGTRL
Tissue Specificity Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced.
Protein Name Sodium-Coupled Monocarboxylate Transporter 1
Apical Iodide Transporter
Electrogenic Sodium Monocarboxylate Cotransporter
Sodium Iodide-Related Cotransporter
Solute Carrier Family 5 Member 8
Database Links Reactome: R-HSA-197264
Reactome: R-HSA-428643
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Expressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells
Alternative Antibody Names Anti-Sodium-Coupled Monocarboxylate Transporter 1 antibody
Anti-Apical Iodide Transporter antibody
Anti-Electrogenic Sodium Monocarboxylate Cotransporter antibody
Anti-Sodium Iodide-Related Cotransporter antibody
Anti-Solute Carrier Family 5 Member 8 antibody
Anti-SLC5A8 antibody
Anti-AIT antibody
Anti-SMCT antibody
Anti-SMCT1 antibody

Information sourced from Uniprot.org