| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC5A6 is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC5A6 |
| Gene ID: |
8884 |
| Uniprot ID: |
SC5A6_HUMAN |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC5A6 (NP_066918.2). |
| Immunogen Sequence: |
TVATVTTLMPLTTFSKPTGL QRFYSLSYLWYSAHNSTTVI VVGLIVSLLTGRMRGRSLNP ATIYPVLPKLLSLLPLSCQK RLHCRSYGQDHLDTGLFPEK PRNGVLGDSRDKEAMALDGT AYQGSSSTCILQETSL |
| Tissue Specificity | Expressed in microvessels of the brain (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. |
| Post Translational Modifications | May be glycosylated. |
| Function | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier. |
| Protein Name | Sodium-Dependent Multivitamin TransporterNa(+-Dependent Multivitamin TransporterHsmvtSolute Carrier Family 5 Member 6 |
| Database Links | Reactome: R-HSA-196780Reactome: R-HSA-199220Reactome: R-HSA-425397 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembranePreferentially Localized At The Luminal Membrane Of Brain Capillary EndotheliumLocalized To The Brush Border/Apical Membrane Of Intestine And Renal Polarized Cells(Microbial Infection) Exposure To EColi Lipopolysaccharides Leads To Reduced Cell Membrane Localization |
| Alternative Antibody Names | Anti-Sodium-Dependent Multivitamin Transporter antibodyAnti-Na(+-Dependent Multivitamin Transporter antibodyAnti-Hsmvt antibodyAnti-Solute Carrier Family 5 Member 6 antibodyAnti-SLC5A6 antibodyAnti-SMVT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
