Anti-SLC5A6 antibody (STJ117014)

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STJ117014

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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC5A6 is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC5A6
Gene ID: 8884
Uniprot ID: SC5A6_HUMAN
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SLC5A6 (NP_066918.2).
Immunogen Sequence: TVATVTTLMPLTTFSKPTGL QRFYSLSYLWYSAHNSTTVI VVGLIVSLLTGRMRGRSLNP ATIYPVLPKLLSLLPLSCQK RLHCRSYGQDHLDTGLFPEK PRNGVLGDSRDKEAMALDGT AYQGSSSTCILQETSL
Tissue Specificity Expressed in microvessels of the brain (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Post Translational Modifications May be glycosylated.
Function Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier.
Protein Name Sodium-Dependent Multivitamin Transporter
Na(+-Dependent Multivitamin Transporter
Hsmvt
Solute Carrier Family 5 Member 6
Database Links Reactome: R-HSA-196780
Reactome: R-HSA-199220
Reactome: R-HSA-425397
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Preferentially Localized At The Luminal Membrane Of Brain Capillary Endothelium
Localized To The Brush Border/Apical Membrane Of Intestine And Renal Polarized Cells
(Microbial Infection) Exposure To E
Coli Lipopolysaccharides Leads To Reduced Cell Membrane Localization
Alternative Antibody Names Anti-Sodium-Dependent Multivitamin Transporter antibody
Anti-Na(+-Dependent Multivitamin Transporter antibody
Anti-Hsmvt antibody
Anti-Solute Carrier Family 5 Member 6 antibody
Anti-SLC5A6 antibody
Anti-SMVT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance