| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC5A11 |
| Gene ID: | 115584 |
| Uniprot ID: | SC5AB_HUMAN |
| Immunogen Region: | 540-640 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-640 of human SLC5A11 (NP_443176.2). |
| Immunogen Sequence: | SWFTEPPSKEMVSHLTWFTR HDPVVQKEQAPPAAPLSLTL SQNGMPEASSSSSVQFEMVQ ENTSKTHSCDMTPKQSKVVK AILWLCGIQEKGKEELPARA E |
| Tissue Specificity | Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. |
| Function | Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
| Protein Name | Sodium/Myo-Inositol Cotransporter 2 Na(+/Myo-Inositol Cotransporter 2 Sodium-Dependent Glucose Cotransporter Sodium/Glucose Cotransporter Kst1 Sodium/Myo-Inositol Transporter 2 Smit2 Solute Carrier Family 5 Member 11 |
| Database Links | Reactome: R-HSA-429593 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Apical Cell Membrane Located On Apical Membrane Of Enterocytes Located On Membrane Of Kidney Brush Border Membrane Vesicles (Bbmvs) And Apical Membrane Of Proximal Convoluted Tubules |
| Alternative Antibody Names | Anti-Sodium/Myo-Inositol Cotransporter 2 antibody Anti-Na(+/Myo-Inositol Cotransporter 2 antibody Anti-Sodium-Dependent Glucose Cotransporter antibody Anti-Sodium/Glucose Cotransporter Kst1 antibody Anti-Sodium/Myo-Inositol Transporter 2 antibody Anti-Smit2 antibody Anti-Solute Carrier Family 5 Member 11 antibody Anti-SLC5A11 antibody Anti-KST1 antibody Anti-SLGTX antibody Anti-SMIT2 antibody |
Information sourced from Uniprot.org