| Tissue Specificity | Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. |
| Function | Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
| Protein Name | Sodium/Myo-Inositol Cotransporter 2Na(+/Myo-Inositol Cotransporter 2Sodium-Dependent Glucose CotransporterSodium/Glucose Cotransporter Kst1Sodium/Myo-Inositol Transporter 2Smit2Solute Carrier Family 5 Member 11 |
| Database Links | Reactome: R-HSA-429593 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocated On Apical Membrane Of EnterocytesLocated On Membrane Of Kidney Brush Border Membrane Vesicles (Bbmvs) And Apical Membrane Of Proximal Convoluted Tubules |
| Alternative Antibody Names | Anti-Sodium/Myo-Inositol Cotransporter 2 antibodyAnti-Na(+/Myo-Inositol Cotransporter 2 antibodyAnti-Sodium-Dependent Glucose Cotransporter antibodyAnti-Sodium/Glucose Cotransporter Kst1 antibodyAnti-Sodium/Myo-Inositol Transporter 2 antibodyAnti-Smit2 antibodyAnti-Solute Carrier Family 5 Member 11 antibodyAnti-SLC5A11 antibodyAnti-KST1 antibodyAnti-SLGTX antibodyAnti-SMIT2 antibody |
Information sourced from Uniprot.org
