| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC5A11 (540-640) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC5A11 |
| Gene ID: |
115584 |
| Uniprot ID: |
SC5AB_HUMAN |
| Immunogen Region: |
540-640 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 540-640 of human SLC5A11 (NP_443176.2). |
| Immunogen Sequence: |
SWFTEPPSKEMVSHLTWFTR HDPVVQKEQAPPAAPLSLTL SQNGMPEASSSSSVQFEMVQ ENTSKTHSCDMTPKQSKVVK AILWLCGIQEKGKEELPARA E |
| Tissue Specificity | Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. |
| Function | Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
| Protein Name | Sodium/Myo-Inositol Cotransporter 2Na(+/Myo-Inositol Cotransporter 2Sodium-Dependent Glucose CotransporterSodium/Glucose Cotransporter Kst1Sodium/Myo-Inositol Transporter 2Smit2Solute Carrier Family 5 Member 11 |
| Database Links | Reactome: R-HSA-429593 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocated On Apical Membrane Of EnterocytesLocated On Membrane Of Kidney Brush Border Membrane Vesicles (Bbmvs) And Apical Membrane Of Proximal Convoluted Tubules |
| Alternative Antibody Names | Anti-Sodium/Myo-Inositol Cotransporter 2 antibodyAnti-Na(+/Myo-Inositol Cotransporter 2 antibodyAnti-Sodium-Dependent Glucose Cotransporter antibodyAnti-Sodium/Glucose Cotransporter Kst1 antibodyAnti-Sodium/Myo-Inositol Transporter 2 antibodyAnti-Smit2 antibodyAnti-Solute Carrier Family 5 Member 11 antibodyAnti-SLC5A11 antibodyAnti-KST1 antibodyAnti-SLGTX antibodyAnti-SMIT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
