Anti-SLC30A6 antibody (252-461) (STJ113247)

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STJ113247
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC30A6
Gene ID: 55676
Uniprot ID: ZNT6_HUMAN
Immunogen Region: 252-461
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 252-461 of human SLC30A6 (NP_060434.2).
Immunogen Sequence: KVLLQTTPPHVIGQLDKLIR EVSTLDGVLEVRNEHFWTLG FGSLAGSVHVRIRRDANEQM VLAHVTNRLYTLVSTLTVQI FKDDWIRPALLSGPVAANVL NFSDHHVIPMPLLKGTDDLN PVTSTPAKPSSPPPEFSFNT PGKNVNPVILLNTQTRPYGF GLNHGHTPYSSMLNQGLGVP GIGATQGLRTGFTNIPSRYG TNNRIGQPRP
Tissue Specificity Expressed in brain.especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.
Function Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
Protein Name Zinc Transporter 6
Znt-6
Solute Carrier Family 30 Member 6
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Zinc Transporter 6 antibody
Anti-Znt-6 antibody
Anti-Solute Carrier Family 30 Member 6 antibody
Anti-SLC30A6 antibody
Anti-ZNT6 antibody

Information sourced from Uniprot.org