| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIPA1L1 |
| Gene ID: |
26037 |
| Uniprot ID: |
SI1L1_HUMAN |
| Immunogen Region: |
1480-1700 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1480-1700 of human SIPA1L1 (NP_056371.1). |
| Immunogen Sequence: |
TSKYLIGWKKPEGTINSVGF MDTRKRHQSDGNEIAHTRLR ASTRDLRASPKPTSKSTIEE DLKKLIDLESPTPESQKSFK FHALSSPQSPFPSTPTSRRA LHRTLSDESIYNSQREHFFT SRASLLDQALPNDVLFSSTY PSLPKSLPLRRPSYTLGMKS LHGEFSASDSSLTDIQETRR QPMPDPGLMPLPDTAADLDW SNLVDAAKAYEVQRASFFAA S |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2. Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome. |
| Function | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. |
| Protein Name | Signal-Induced Proliferation-Associated 1-Like Protein 1Sipa1-Like Protein 1High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1E6-Targeted Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCytoskeletonPostsynaptic DensitySynapseSynaptosomeAssociated With The Actin CytoskeletonDetected At Synapses And Dendritic Spines Of Cultured Hippocampal Neurons |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated 1-Like Protein 1 antibodyAnti-Sipa1-Like Protein 1 antibodyAnti-High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 antibodyAnti-E6-Targeted Protein 1 antibodyAnti-SIPA1L1 antibodyAnti-E6TP1 antibodyAnti-KIAA0440 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
