| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SGK2 (228-367) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SGK2 |
| Gene ID: |
10110 |
| Uniprot ID: |
SGK2_HUMAN |
| Immunogen Region: |
228-367 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 228-367 of human SGK2 (NP_733794.1). |
| Immunogen Sequence: |
LHGLPPFYSQDVSQMYENIL HQPLQIPGGRTVAACDLLQS LLHKDQRQRLGSKADFLEIK NHVFFSPINWDDLYHKRLTP PFNPNVTGPADLKHFDPEFT QEAVSKSIGCTPDTVASSSG ASSAFLGFSYAPEDDDILDC |
| Tissue Specificity | Highly expressed in liver, kidney and pancreas, and at lower levels in brain. |
| Post Translational Modifications | Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193. |
| Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Protein Name | Serine/Threonine-Protein Kinase Sgk2Serum/Glucocorticoid-Regulated Kinase 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sgk2 antibodyAnti-Serum/Glucocorticoid-Regulated Kinase 2 antibodyAnti-SGK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
