| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SETDB2 (148-378) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SETDB2 |
| Gene ID: |
83852 |
| Uniprot ID: |
SETB2_HUMAN |
| Immunogen Region: |
148-378 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 148-378 of human SETDB2 (NP_114121.2). |
| Immunogen Sequence: |
SGACLMKMPLNLKGENPLQL PIKCHFQRRHAKTNSHSSAL HVSYKTPCGRSLRNVEEVFR YLLETECNFLFTDNFSFNTY VQLARNYPKQKEVVSDVDIS NGVESVPISFCNEIDSRKLP QFKYRKTVWPRAYNLTNFSS MFTDSCDCSEGCIDITKCAC LQLTARNAKTSPLSSDKITT GYKYKRLQRQIPTGIYECSL LCKCNRQLCQNRVVQHGPQV RLQVFKTEQKG |
| Tissue Specificity | Ubiquitous. Highest expression in heart, testis and ovary. |
| Function | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. |
| Protein Name | Histone-Lysine N-Methyltransferase Setdb2Chronic Lymphocytic Leukemia Deletion Region Gene 8 ProteinLysine N-Methyltransferase 1fSet Domain Bifurcated 2 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setdb2 antibodyAnti-Chronic Lymphocytic Leukemia Deletion Region Gene 8 Protein antibodyAnti-Lysine N-Methyltransferase 1f antibodyAnti-Set Domain Bifurcated 2 antibodyAnti-SETDB2 antibodyAnti-C13orf4 antibodyAnti-CLLD8 antibodyAnti-KMT1F antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
