| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SERPIND1 (20-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPIND1 |
| Gene ID: |
3053 |
| Uniprot ID: |
HEP2_HUMAN |
| Immunogen Region: |
20-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-290 of human SERPIND1 (NP_000176.2). |
| Immunogen Sequence: |
GSKGPLDQLEKGGETAQSAD PQWEQLNNKNLSMPLLPADF HKENTVTNDWIPEGEEDDDY LDLEKIFSEDDDYIDIVDSL SVSPTDSDVSAGNILQLFHG KSRIQRLNILNAKFAFNLYR VLKDQVNTFDNIFIAPVGIS TAMGMISLGLKGETHEQVHS ILHFKDFVNASSKYEITTIH NLFRKLTHRLFRRNFGYTLR SVNDLYIQKQFPILLDFKTK VREYYFAEAQIADFSDPAF |
| Tissue Specificity | Expressed predominantly in liver. Also present in plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. |
| Protein Name | Heparin Cofactor 2Heparin Cofactor IiHc-IiProtease Inhibitor Leuserpin-2Hls2Serpin D1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Alternative Antibody Names | Anti-Heparin Cofactor 2 antibodyAnti-Heparin Cofactor Ii antibodyAnti-Hc-Ii antibodyAnti-Protease Inhibitor Leuserpin-2 antibodyAnti-Hls2 antibodyAnti-Serpin D1 antibodyAnti-SERPIND1 antibodyAnti-HCF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
